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Cancer is a complex and dynamic disease that is aberrant both biologically and physically. There is growing appreciation that physical abnormalities with both cancer cells and their microenvironment that span multiple length scales are important drivers for cancer growth and metastasis. The scope of this review is to highlight the key advancements in micro‐ and nanoscale tools for delineating the cause and consequences of the aberrant physical properties of tumors. Herein, the following three important physical aspects of cancer are focused: 1) solid mechanical properties, 2) fluid mechanical properties, and 3) mechanical alterations to cancer cells. Beyond posing physical barriers to the delivery of cancer therapeutics, these properties are also known to influence numerous biological processes, including cancer cell invasion and migration leading to metastasis, and response and resistance to therapy. There is a comment on how micro‐ and nanoscale tools have transformed the fundamental understanding of the physical dynamics of cancer progression and their potential for bridging toward future applications at the interface of oncology and physical sciences.